Health Systems Action

Precision medicine

Personalised Prevention: Fattening the Cow or Just Weighing It?

Introduction Despite being underfunded for over a decade, and now in “critical condition”, the UK’s National Health System (NHS) has significantly invested in personalised medicine. These initiatives include the pioneering 100,000 Genomes Project, genetically based cancer screening, and personalised prevention. Proponents argue these programmes will improve outcomes and reduce pressure on the healthcare system. Critics …

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Polygenic Risk Scores for Africa?

Despite the huge excitement that greeted the sequencing of the first human genome at the turn of the century, genetic testing isn’t routine. When will this change? Historically, genetic testing was reserved for patients with known or suspected genetic disorders. Tests could identify single gene (“monogenic”) changes linked to conditions like sickle cell disease, haemophilia …

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